Updates on Ashley, Donald, Henry and Melissa since their weight-loss journeys were chronicled. Inclu...

Pivotal moments, whether tragic breaking points or ultimate triumphs, decide the success or failure...

Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, a...

650-lb Melissa begins her seven-year weight loss journey.

650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend h...

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to t...

Zsaylnn, once known as the "Fat Girl Rock Star" - married a man who loves large women. Now weighing...

Battling severe depression in the wake of a suicide attempt, 46-year old Olivia hasn't left her Chic...

Bedridden for four years, 46-year old Penny knows that her weight may kill her if drastic actions ar...

Chuck weighs almost 700lbs and it has hindered every aspect of his life. He's had to downsize his bu...

Christina is a 22-year old married woman from South Haven, Mississippi, who hasn't left her house in...

Paula has had a tough life, and at over 600lbs, has built a physical wall around herself to push peo...

James comes from a long line of family obesity and at 706lbs, is determined not to die in the same h...

Tara is a mother of two from Lafayette, LA. Addicted to food, she is too ashamed of her size to be s...

At age 23, and over 600-lbs, Amber relies on her family, and boyfriend for even simple needs. Her fe...

Weighing in at over 600-lbs, 37 year old Susan is committed to drastic weight loss. But, when an unf...

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over...

At just 24, Bettie Jo is eating her way towards 700-lbs. Housebound, she is reliant on her husband f...

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and...

Joe is only 30, and trapped in an 800-lb body. He lost his job and is mostly housebound. Can Joe fin...

Laura has used food to cope with her emotions for too long. Confined to a wheelchair, relying on an...

Charity weighs nearly 800-lbs. Suffering from flesh-eating bacteria and butterfly shaped fat deposit...

Chay is just 23, but to cope with the emotional turmoil of his childhood he has eaten his way to 600...

Marla is so heavy she cannot stand up. Bedridden, her true weight is unknown but estimated at 800-lb...

Nikki's life and career are threatened by her 650-pound weight. Determined to make a change, she und...

Brittani has reached almost 600 pounds at just 32 years old. Though her husband loves large women, s...

At over 700 pounds, Chad's weight is out of control and gastric bypass surgery is his last resort. H...

June, at almost 600 pounds, has coped with the tragic death of her son by eating. Confined to her ho...

At over 600 pounds, Dottie agrees to a drastic new diet and gastric bypass surgery in hopes of recla...

At over 600 pounds, Gideon's is unable to work and completely dependent on his exhausted wife. Feari...

Ashley is just 26 years old and over 700 pounds. Her 5-year-old son is one of her primary caregivers...

At over 700 pounds, Teretha's life is confined to a bed -- a far cry from her former job representin...

At 650 pounds, Randy's weight has led to the loss of his marriage and custody of his daughter. In a...

At about 700 pounds, Milla is bedridden and unable to feed or bathe herself -- her five children car...

Sean weighs almost 1,000 pounds at just 26 years old. His skin is so stretched it is tearing apart,...

Lupe, at almost 600 pounds, has been bedridden for 10 years and depends on her husband for all her n...

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losi...

At 670 pounds Ashley must live in her parents' home with her husband. Desperate to save her life and...

Cynthia is a 610-lb single mother raising five kids. She's been focused on her children, but now rea...

Weighing over 600-lbs Kirsten is close to losing her mobility. While she's trying to get control of...

After overcoming a dependence on drugs & alcohol, sneaking food is 660-lb Doug's last remaining vice...

At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but the...

Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of h...

Michael's massive 632lb body has left him completely dependent upon his family. If he doesn't learn...

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying t...

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tra...

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only hav...

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs. They're so mas...

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the...

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses o...

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and...

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emoti...

A devoted girlfriend and loving aunt, Alicia is all smiles and laughter on the outside, but on the i...

A woman with two children weighs more than 600 pounds, so she agrees to go on an extreme new diet, b...

James LB Bonner spent his early life trying to prove himself to his adoptive family, but after losin...

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her bro...

Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will ne...

After years of a tumultuous relationship with her husband, Tamy's eating addiction causes her weight...

Fearing that he'll suffer the same fate as older brother David, now 700 pounds and unable to work, B...

A former plus-size model and "big is beautiful" advocate, Renee realizes the mortal mistakes she mad...

A 24-year-old woman weighs more than 600 pounds and is fighting for her life after a difficult child...

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop re...

Jennifer and her daughter, Marissa, are stuck in a co-dependent relationship that puts both of their...

A 400-lb. woman learns that she's pregnant, but wonders if she'll be able to deliver the baby withou...

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems an...

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help...

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unex...

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit...

A college graduate with a once-promising career, Justin has eaten his life away to the point of neve...

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than cha...

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for succes...

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to los...

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend...

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, T...

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgen...

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 p...

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food...

Kelly is on the verge of immobility when she decided to make the trip to Houston to visit Dr. Now; H...

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her we...

When Annjeannette was 9, a campaign was established to send her to fat camp. She hated that her weig...

A mother of 4, bed-bound for 2 years, Lashanta relies on her kids to keep her cleaned and fed. Her l...

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, an...

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weig...

Weighing over 600 lbs. each, Vianey and Allen are locked in a codependent relationship based on a sh...

John & Lonnie are two brothers from opposite ends of the spectrum. For years estranged, the brothers...

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens...

Bethany has two daughters who live in fear of losing their mom to her food addiction. Once an addict...

J.T. is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to...

When Travis got too big to walk down the aisle, he promised to give his wife a proper wedding one da...

Joyce needs home health care 24/7 and hasn't left the house in years. But getting to Dr. Now in Hous...

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600+ lbs each, ne...

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain th...

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daug...

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of, but t...

The four best reasons for Coliesa to live are her daughters. But after a heart attack and losing the...

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with...

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan ca...

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has onl...

At nearly 1,000 pounds, Samantha is dangerously close to dying. To make matters worse, she's paid to...

Thederick has become housebound from eating, and for 10 years, he's only gone outside to greet the i...

20 years after her dad died as a result of a botched weight loss surgery, Carrie is on the brink of...

Cindy is resistant to change and has spent years creating a world that makes her feel safe. When her...

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her fo...

Kenae' was already big before her weight gain took off after the death of her beloved mother. Refusi...

Krystal began overeating to shield herself with a protective layer of obesity after suffering years...

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While l...

A lifetime of abuse and ridicule has left Michael anxious and afraid to leave the house. Now with th...

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedri...

Irene had to move back in with her son because her weight made it unbearable to live on her own. Whe...

Through tough times, food has always been Tammy's friend. But now she has gotten so big that her dau...

Having her daughters help bathe her is not how Chrystal pictured parenting, but she is so large now...

When Nathan's weight gets in the way of the only healthy thing in his life - his job as a drama teac...

For Julian and his wife, Irma, it was love at first sight. But in order to grow old together, Julian...

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help w...

Mike was born with a talent for sports -- and an omnivorous appetite to match. After his football dr...

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her fro...

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to liv...

Ryan moved to Montana to keep himself from going down a dark path of drug addiction. However, his ne...

For James B, food means family. He grew up eating rich Haitian food and loves it with a passion. Now...

Living on a homestead with his family, Lucas wants to spread his wings and fly, but at 600 pounds, h...

Margaret's life at 700 pounds is in need of a jump start. At age 35, she is a mama's girl. Now, it's...

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to be...

Dolly has gotten too comfortable at 600 pounds. There's physical pain all over, and the skin apron p...

For Larry, a second weight loss surgery would mean a second chance at a career as a gospel recording...

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy. But...

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of sel...

As an Italian American, Geno was raised with lots of love, family and food. Now, he's still living w...

Latonya found the man she wants to marry. The only problem is that, at almost 700 pounds, she can't...

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, D...

Syreeta thinks that anyone trying to help has an ulterior motive, but now she's gotten so big she de...

Mark sets out with a goal for weight loss surgery, but as weight loss gets easier, he turns down med...

With her weight spiraling, Stephanie needs her mom's help to care for her three kids. Now, she's at...

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is fa...

Patrick's weight has never been a bother -- not to him, nor to his wife, Amanda. Now, however, he's...

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can...

William was always mobile and fairly athletic -- that is, until he wasn't. It's been years now since...

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how...

Abi was struggling with his weight before a fluke accident left him mostly paralyzed. Bedbound for s...

At 58, Rose had given up on life. But for her family's sake she resolves to lose over 400 pounds no...

Shakyia's severe obesity worsened when she became a shut-in. Despite her sister's encouragement, mee...

Recovering addict Charles replaces drugs with food. Morbidly obese, he needs Dr. Now but his brother...

Jonathan had his dream job, and he ate himself out of it; once an EMT first responder, he rarely lea...

Krystal has never let her weight get in the way, but the truth is her weight has really started gett...

Karen has gotten so out of control with her eating that she's developed a fear of leaving the house;...

Gary doesn't leave the bed anymore, he has his mom and a bevy of caretakers to get him what he needs...

At 6'3 and over 700 pounds, Jacky has barely had a chance to live; she's never fit in anywhere; now...

Deshaun takes being protective of his mom to the next level. He's over 700 pounds and won't leave hi...

Pastor Juan's love of food made him overweight, but it has never been a problem until recently, sinc...