Michaela "Mike" Quinn, of Boston, followed in her father's footsteps by becoming a doctor. Dr. Mike...

Horror mounts when a flu epidemic attacks Colorado Springs. Dr. Mike must attend the sick townspeopl...

Mike's estranged mother (Jane Wyman) visits, but she and Mike are still miles apart. Meanwhile, Robe...

A gunslinger (Johnny Cash) arrives looking for a quiet town in which to hang 'em up, but Colorado Sp...

A bitter Loren, who blames Sully for his daughter's death, tries to repossess Dr. Mike's cabin when...

As Dr. Quinn is trying to persuade the townspeople that smallpox vaccinations are necessary, the fat...

When several townspeople come down with mercury poisoning, Dr. Mike forces a reluctant Sully to guid...

Dr. Mike tries to heal the soul of Doc Eli, a Civil War surgeon turned patent medicine show huckster...

Dr. Mike takes in Red McCall, a down-and-out cowboy, and his ailing half-breed infant child. McCall...

Sully ends up badly beaten and partially paralyzed following a run in with buffalo hunters who were...

After ambushing Black Kettle's camp, General Custer enters the town carrying wounded soldiers and In...

After a patient of Dr. Mike's dies of blood poisoning, she accuses Jake, the barber, of infecting th...

Matthew's sudden announcement that he wants to marry Ingrid causes upheaval in his relationship with...

Colleen develops a teenage crush on Sully after he pulls her out of the path of a runaway wagon. Ima...

While Brian and Sully are out hiking, Brian climbs a tree and jumps out before Sully can stop him. B...

When Mike and Sully stop to check on old Mrs. Johnson, they discover her dead and a young boy, Zack,...

David Watkins, a civil war photographer arrives in Colorado Springs. Dr. Mike diagnoses David's diab...

After Snowbird gives Mike an Indian pony, Flash, in thanks for her work at the reservation Mike trie...

Dorothy, Loren's sister-in-law and old flame, is introduced as an abused wife who defends herself ag...

Halloween is trick-or-treat for the residents of Colorado Springs when Sully's dead wife, Abigail, h...

Jake, Loren and Horace are out hunting when Jake, mistaking an Indian for a deer, accidentally shoot...

Love finds visiting faith healer Sister Ruth, in the form of Kid Cole, who's revisiting the town in...

Mike receives an emergency telegram from her sister Rebecca -- her mother is gravely ill. Mike rushe...

Sully arrives in Boston and discovers that he's facing worthy competition for Mike's affection in th...

Mike and Sully have trouble adjusting to the new status of their relationship, ""courtin'"". Sully i...

Colleen and Becky become best friends when, at Bray's store, Alice, another friend, insists on takin...

Mike is called away to Soda Springs to help with an outbreak of influenza and Sully promises to stay...

Mike's Christmas Eve gets off to a bad start, triggering a personal crisis for Mike. Through no faul...

Miners gather in front of Loren Bray's store to protest Loren's not extending credit to striking min...

Mike and Sully work to treat a typhus epidemic at Black Kettle's camp, which begins after Mike and S...

A ragtag circus, consisting only of Heart and Atlantis, a mother-and-daughter team, arrives in Color...

Catherine, a beautiful blond woman captured by and raised with renegade Indians, is brought to Color...

Eight orphans arrive on the train. The Reverend takes them in at the church and Mike nurses their ai...

A troop of black cavalry soldiers ride into town intending to cover themselves in glory by eradicati...

When Julius Hoffman rides into town and engages Matthew in a poker game, Matthew thinks he's found a...

Tom Jennings, Dorothy's son, shows up in Loren's store one day when Mike and the kids are there shop...

Robert E buys a house in town. When the auctioneer, Jedediah Bancroft, sees that he's sold the house...

Rev. Johnson's in love with the town's new schoolteacher (Sherry Hursey), while Mike's concerned abo...

Mike and Sully get caught in the crossfire when, while visiting the Indian reservation, they see ren...

Sully sets out to rescue Mike. Meanwhile, Custer takes the Indian reservation hostage, threatening t...

Mike and Jake go head-to-head when both campaign for the Mayorship of Colorado Springs. At issue: wh...

Only the town's love for the infinitely unlovable Hank can pull him from the brink of a deadly coma....

When ""Andrew Strauss""—really David Lewis—the fiancé whom Mike had presumed was killed in the...

Mike is torn between two lovers when, in a blast from the past, her presumed-dead Civil War fiance,...

Sully argues with Mike that they should move if the railroad comes. Meanwhile, Matthew feels left-ou...

Loren plans a trip to Bolivia to prove he is not getting old; Brian seeks to prove his courage by ca...

Mike receives a telegram from Miss Olive - she's ill - but when she, family and friends arrive in Me...

Matthew and Sully quarrel over the route of the cattle drive.

Mike tangles with the usually benevolent Reverend when she donates books to the town and he tries to...

Mike helps John, a man Brian finds in the woods, deal with outer and inner scars when she operates o...

Mike, Sully, and Cloud Dancing head to Washington, D.C., to lobby on behalf of the Indians.

Sully is imprisoned when he accompanies Dr. Mike and Cloud Dancing to Washington to lobby on behalf...

Mike and Sully battle money issues when Sully wants to be the primary provider and Mike wants to com...

Mike and Sully run into now-married Kid Cole and Sister Ruth and invite them home for Thanksgiving,...

Mike discovers a lump in Dorothy's breast and performs a mastectomy on her. Meanwhile, Colleen must...

Dorothy insists the decision to have surgery is hers, not Mike's; Colleen finds the harassment unbea...

Mike intervenes in their behalf when a Jewish peddler family arrives in town and is met with prejudi...

Sully takes a job as an Indian Agent, only to discover corruption's rife within the system. Meanwhil...

Mike remains the sole voice of reason when townsfolk read a newspaper article predicting that a come...

Mike learns some patients are beyond help when she climbs Pike's Peak to follow a woman who's chosen...

Mike loses custody of Brian and Colleen when their father, Ethan Cooper, arrives with new bride Lill...

Brian and Colleen run away from Ethan and Lillian, and Colleen contracts potentially lethal pneumoni...

Brian's homework assignment, an essay entitled, ""What Is Love?"" to be written in honor of Valentin...

Mike volunteers Robert E's services to fix a steam engine for the railroad, but whether Robert E can...

When teen-outlaw Belle Starr robs the saloon, Mike takes her in, intending to reform her; Colleen ov...

A paleontologist arrives in town, igniting ""bone fever"" among the townsfolk when he announces that...

With no child-protection laws, and influenced by Charles Darwin's theory of evolution, Mike has a gi...

Mike and Sully arrive too late to avert Custer's slaughter of the Indians at the Washita River; Bria...

Sully and the kids must help Mike deal with the emotional aftermath of the Washita massacre; Robert...

After discovering a badly injured Loren, Sully must battle his own demons in order to save him.

Mike and Sully go to the Reverend for a dose of preventative pre-marital counseling, and recall the...

Mike's mother arrives with elaborate wedding plans; Custer puts a bounty on best man Cloud Dancing.

While Sully is off thinking and doesn't return for several days, Mike gets worried. Although Mike co...

The honeymoon is over for Mike and Sully as the newlyweds must adjust to life in a changing Colorado...

The town invites a traveling all-star baseball team for a fundraising event, but later suspects that...

Mike is overwhelmed with her new found passion for Sully, and feeling slighted, Colleen joins her sc...

Matthew's fiance Ingrid hovers near death after being bitten by Brian's rabid pet wolf; Brian is ove...

An elderly man comes to town with hopes that the natural spring will help his rheumatism. Dr. Mike c...

Dorothy Jennings' book about her experiences in Colorado Springs becomes a best seller, but it anger...

Loren proposes to Dorothy but suffers a stroke before she can give him an answer. Meanwhile, Sully f...

Dr. Mike celebrates her birthday by climbing Pikes Peak with Dorothy, Grace and Myra, but ends up in...

Dorothy, Myra and Grace realize they are quitting and they're letting Mike down, so they decide to g...

At Thanksgiving, Mike faces the possibility that she might be infertile, while Jake struggles with t...

The family finds Matthew running a saloon at a railroad camp where his grief over Ingrid's death dri...

As Colorado Springs prepares for Christmas, the family receives a rambunctious toy poodle from Mike'...

Robert E and Grace want to adopt a young boy who is suffering from a disease Mike can't diagnose (si...

Increasing lawlessness in Colorado Springs sparks a demand for a new sheriff, and Matthew feels he's...

Matthew falls for an independent young woman, but the fact that she's a prostitute complicates their...

The town is duped by two con men selling shares in a refrigeration box and Mike must turn the tables...

Sully pursues a renegade mountain man who has kidnapped senator Leonard's son, in protest of the Sen...

The rescuers get ugly after Leonard offers a bounty for the mountain man, so Sully sets off alone.

The Reverend mortgages the church to Hank to get money to make church repairs in order to impress hi...

Feelings run high after a drifter is sentenced to hang for rape and murder

Cloud Dancing sees a reservation school as fatal to Indian culture; bankers stonewall Dorothy's loan...

Dr. Mike's joyful reunion with a college friend soon turns competitive; Dorothy struggles with a new...

Tales of her accomplishments embarrass Woman of the Year nominee Mike; Hank's grandmother visits.

A renegade stabs Cloud Dancing, and Emma has a tumor, so Mike cannot slow down before the baby is bo...

A popular new arrival carries a dread disease; Preston plans an exclusive clinic.

Cloud Dancing hopes his trial for shooting a soldier will unite the tribes.

Dr. Mike prepares for the birth of her baby. Mike's family arrives for the impending birth of Mike a...

Wounded Sully must deliver Mike's baby. Dr. Cook is forced to perform a major operation. Katie Sully...

Sully goes to Denver to negotiate the release of Cloud Dancing from the army. One of the conditions...

Michaela has returned to work after being home with Katie. Between work, the baby and being so tired...

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in cha...

The appearance of renowned singer Gilda St. Clair (Barbara Mandrell) tempts Colleen to leave college...

A Latin American woman rebuffs Dr. Mike's attempts at friendship; the Rev. Johnson searches for a te...

Dr. Mike faces the prospect of leaving her practice and friends for Wyoming when Sully is offered a...

Dr. Mike is arrested and put in jail for treating a fugitive Indian; Jake and Preston run against ea...

A sick and ragged prospector wanders into town and Jake Slicker recognizes the man as his father, wh...

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded...

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mi...

Grace and Robert E. encounter fierce opposition when they attempt to enroll their son in the town's...

When three people die after coming in contact with something in the clinic, and one is deathly sick,...

As Christmas approaches, Brian questions his faith when he learns that Dr. Mike cannot save the sigh...

In a case of mistaken motivation, a judge sends Sully to prison after he is spotted with criminals b...

Dr. Mike's Uncle Theodore, a concert pianist, sees in Brian not only a talented musician, but his ow...

Kid Cole and Sister Ruth (Johnny Cash and June Carter Cash) visit Dr. Mike at a difficult time in th...

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr...

An old friend of Sully's visits, wanting to financially help the family. Although he falls in love w...

While Sully is away for a few days to procure some money, Preston arrives threatening to repossess t...

Sully, depite being wounded by two bank robbers, works to free his wife, Brian and Katie when they a...

Brian takes a liking to visiting writer Walt Whitman, even when the townspeople shun Whitman over ru...

Sully arranges an escape for Cloud Dancing, leading him and the Indian to become wanted men.

After Marjorie joins the Women's movement she blows into town stirring everyone up and has a fling w...

Everyone is doting on Katie and Brian feels slighted. Brian receives a letter and picture from his r...

Cloud Dancing is badly beaten by soldiers for returning late to the reservation. Michaela treats him...

Sully lies to everyone about what he is doing, but the truth comes out. Cloud Dancing flees to the T...

Sgt. O'Connor was found dead in the river. Sully is nowhere to be found. Michaela believes that he s...

Sully is found alive, but badly hurt. As Michaela nurses him back to health, she keeps him hidden fr...

Sully is wanted for treason and murder. In order to keep him safe, Michaela pretends that Sully is d...

Michaela finds out that she is pregnant, but suffers a miscarriage. Without Sully there to comfort h...

Russian Princess Nizamoff (Natasha Andreichenko) who claims to see the future, tells everyone what t...

Anthony's (Brandon Hammond) health deteriorates rapidly. Grace does not want to face the inevitable....

Marjorie brings a group of Temperance Women (opposed to alcohol consumption) to C.S. Jake goes on a...

A diptheria epidemic sweeps through C.S. Michaela performs a procedure that is not a proven cure. Be...

Mrs. Quinn wants to take to the children to Boston with her. She also disapproves of Loren and Marjo...

Dorothy discovers the deed to the property that Grace's cafe is on. Hank accidently breaks Horace's...

Consumption hits Black Moon and his men. Black Moon agrees to surrender in exchange for safe passage...

Sully and Michaela are on their way home for Christmas, when they stop to help a couple inexperience...

Michaela is shot at the clinic by a man that has a grievance with doctors. The physical wounds heal,...

A male acquaintance of Colleen's from Denver, starts to call on her. When the man pushes himself on...

Loneliness pervades C.S. as the Sweetheart's Dance approaches. Loren sells his store to Preston and...

Chinese immigrants set up camp. Dr. Quinn discovers a young woman (Yumi Iwami) posing as a man in or...

Hank captures Cloud Dancing and gets the army to send him to a reservation far away. Jake and Teresa...

Michaela worries about Brian's friendship with an eccentric man (Martin Von Hoffman) who thinks he i...

U.S. Marshall Elias Burch (guest star Willie Nelson) asks Matthew, still a student of law, to defend...

While away with Sully, Michaela falls and hits her head. She suffers a concussion. The pain of losin...

Robert E releases anger over his separation from Grace through his furious fists in the boxing ring,...

Dr. Mike's elation at Colleen's acceptance to medical school quickly turns to disappointment when Co...