Jane is a young woman with Asperger's syndrome who is living with her parents in Queens, New York. Bianca is her extremely protective older sister who is now moving in with her fiancé, Rob, in Brooklyn. Jane's parents are now moving to the suburbs of New Jersey and they want Jane to move in with Bianca. Bianca and Rob are not sure once they are ready for that kind of responsibility though, and Jane decides she wants her first boyfriend. This causes some strife to the point where it chafes at Jane's growing independence despite ambient noise creeping into her attention. Eventually, this leads to Bianca trying to dissuade one of her friends, Jack, from dating Jane as she views him as too unreliable for her sister.